Although research into treatments for cardiovascular disease has made great strides in recent decades, heart disease still kills nearly 18 million people worldwide each year.
A small, practical model of the human ventricle opens up new horizons in the development of new drugs and therapies, and the study of the development of cardiovascular disease, providing researchers with an ethical and more accurate alternative to the current approach. There is a possibility.
Researchers at the University of Toronto and the University of Montreal (Canada) have found a 1‑millimeter (0.04 inch) long blood vessel that not only beats like the real thing, but also pumps fluid like the muscular outflow chamber of the human embryo’s heart. is created.
“This model can measure the amount and pressure of fluid that is expelled each time the ventricle contracts,” explains Sargol Ohovatian, a biomedical engineer at the University of Toronto.
“Both were hardly possible with previous models.”
There are usually only a handful of options for finding out how a sick or healthy heart sheds blood.
Organs that are no longer fully functional, such as those removed at the time of dissection, exhibit authenticity without activity.
Tissue culture provides a window for understanding biochemical functions, but it does not provide a complete picture of the hydraulic characteristics of pulsating masses in three dimensions.
Animal models allow researchers to test how the living heart functions as a pump under the influence of newly developed therapies, but it is not always the most ethical option. not.
This new heart-like organ rides on the waves of a three-dimensional model of a body part that develops and behaves as nature intended (it never becomes a fully functional organ), mixing synthetic and biological materials. It was grown in the laboratory.
Cells obtained from the cardiovascular tissue of young rats were grown on a polymer-printed scaffold layer with grooves to induce tissue growth.